HomePage of Aleksandras Gutmanas

Aleksandras Gutmanas

Deptartment of Biochemistry and Biophysics
Lundberg laboratory
Gothenburg University
405 30 Gothenburg
Sweden
email: alex@bcbp.gu.se
phone: +46 (0) 31 778 74 36 (home)

+46 (0) 31 773 39 47 (laboratory)
fax: +46 (0) 31 773 39 10 (laboratory)

The current project is a continuation of the Master Thesis, and is MD simulations of the Antennapedia homeodomain and DNA complex. Mutations of one side chain (Gln50 to Lys) in a very closely related fushi-tarazu homeodomain lead to switching of the specificity for the DNA binding from CCATTA to GGATTA. The ns simulations of the four complexes of the wild type and mutant protein and DNA are carried out by AMBER5 program suite. The preliminary results indicate that the wild type protein, complexed to the original DNA sequence, and the mutant protein with the exchanged sequence form significantly more specific intermolecular contacts than the "wrong" complexed homeodomain.

Wait for quite a while, and this page will be very nice!
In the meantime, go and have a look at the page of
Anders Bergkvist